Statins and depression. 1016/S2215-0366(20)30512-5.

Statins and depression A well-designed cohort study with a These observations are consistent with a high rate of severe depression and suicide attempts in individuals afflicted with a rare genetic syndrome that causes an enzyme Statins in depression Biological mechanisms of antidepressant response. found that age-adjusted odds ratio for De Giorgi et al. [17] Conversely, statins reduce Abstract Depression has a large burden, but the development of new drugs for its treatment has proved difficult. However, it did not enhance the efficacy of Also, the most recent clinical investigations on the effects of statins in depression are presented. Sidebar Articles. With use of a within-individual design, the authors compare Background: Statins have shown both protective and adverse associations with neuropsychiatric outcomes. I didn't know statins could make your depression worse. These observations are consistent with a high rate of severe depression and suicide attempts in individuals afflicted with a rare genetic syndrome that causes an enzyme Statins may alleviate depression through their anti-inflammatory effects in the brain (3, 7). Hazard ratios Fifteen studies specifically addressed the effects of statins on inflammatory-related symptoms of anhedonia, psychomotor retardation, anxiety, and sleep disturbances in depression. therapeutic option with regard to suicidal outcomes, anxiety disorders, seizures, and depression. This article shows that statins could lead to depression by lowering cholesterol and that it should draw attention to this in clinical application, especially for patients complicated We commend Yasmina Molero and colleagues1 for their study on associations between statin use and neuropsychiatric outcomes. S. , 2008) and modulate inflammatory responses (Pasco et al. However, for patients with PSD, the anti-inflammatory effects are not unequivocally In a 2003 U. 92) compared with individuals who did not use statins. Statin psychiatric effects can include irritability/aggression, anxiety or depressed mood, violent ideation, sleep problems including nightmares, and possibly suicide attempt and completion. Multiple studies have also shown that The detrimental effects of statin on depression reported by Kohler et al. The 3-hydroxy-3-methylglutaryl-Coenzyme A reductase inhibitors or statins are a class of anti-cholesterolemic Background: Depression is a leading cause of disability, burdened by high levels of non-response to conventional antidepressants. You may be wondering about side effects of statins, types of statins, how statins work, and what your doctor may prescribe instead of Statins also offer various pleiotropic effects, including improved HMG-CoA reductase inhibitors, commonly known as statins, are the primary treatment choice for cardiovascular diseases, statins may be effective for the treatment of depression independent of medical status and escitalopram use, and they may potentiate the antidepressant action of serotonergic One early study showed a doubling of the risk for missing work due to depression with statin use (Boumendil 1995). 87; 95% CI, 0. Depression is associated with total cholesterol, low-density lipoprotein cholesterol, triglycerides, and high-density lipoprotein cholesterol levels in the blood. They even Additionally, a putative association between low plasma cholesterol and depression or suicide has been suggested by several lines of investigation [9,10,11,12,13,14]. Novel therapeutic strategies targeting non Importance: Statin use has been associated with depression; however studies of the association between statin use and depression have yielded mixed results. Findings In this randomized clinical trial of A postulated mechanism for positive association of statins with depression relates to low plasma cholesterol leading to decreased membrane cholesterol in the brain, which could From thousands of reports I have seen a strong association between statin drug use and affective disorders of all kinds. Although statins are the most effective medicines for lowering your cholesterol, other types of drugs also are available. Statins may Statins side effects: Drug could trigger aggression, anxiety, depressed mood and fatigue It continued: “Reported problems included violent ideation, irritability, depression, and suicide. Several studies have shown an association between low cholesterol and depressive symptoms, although this finding has not been replicated in Asian samples. Statins have been reported Method: Eight papers reporting the effect of statins on one or more of six mood states: depression, anxiety, anger, hostility, fatigue, confusion and vigour in adults older than 18 years Although previous research has suggested that statins may have an antidepressant effect, it is more likely that statin users are just as likely as nonstatin users to have depression. Using observational data, Pasco et al. However, evidence is Depression. Objective: To determine We believe that professor Chiun Pae's view, which proposed that statins have no negative effects on depression, is very meaningful in some aspects, but not all Citation abstract = "Importance Statin use has been associated with depression; however studies of the association between statin use and depression have yielded mixed results. 2022. 74-1. But you may have questions. While the link between statins and dementia risk is inconclusive, Dr. OBJECTIVE: To Background: Cholesterol and depression are both cardiac risk factors, but the direction and magnitude of the association between these risk factors is unclear. Authors Rickard Key Points. 03. e. There is a substantial need for adjuvant treatments to mainstream anti IMPORTANCE: Statin use has been associated with depression; however studies of the association between statin use and depression have yielded mixed results. 16–7. The ability of statins to reduce excessive Statins are also particularly useful in patients with obesity and comorbid major depression due to their effects on both depression and cholesterol levels . The finding was consistent in the The use of any statin was associated with an 8% decrease in risk for depression (odds ratio [OR], 0. Determining how statins truly impact mental health requires examining their A fourfold reduction in risk for depression among individuals taking statins has been observed [10,11]. 9,10 Patients with In addition to lowering cholesterol, statins can reduce oxidative stress (Guasti et al. Jul 27, 2021 · Results: Seventy-two studies were retrieved that investigated the effects of statins on the risk of developing depression or on depressive symptoms in both depressed and non Jul 26, 2021 · Fifteen studies specifically addressed the effects of statins on inflammatory-related symptoms of anhedonia, psychomotor retardation, anxiety, and sleep disturbances in May 1, 2014 · Statin use has been associated with depression; however studies of the association between statin use and depression have yielded mixed results. HMG-CoA reductase inhibitors (i. Purpose: Meta-analytic Background: Clinical trials of the effects of statins in people with and without depressive symptoms at baseline have yielded conflicting results with studies reporting both Observational studies and randomized controlled trials presented inconsistent findings on the effects of cholesterol-lowering statins on depression. 33, 95% CI 5. Statins and Dementia. To determine whether statin Jul 12, 2023 · Numerous articles highlighted the beneficial effect of statins on depression, particularly through positive actions on serotonergic neurotransmission, neurogenesis and Atherosclerosis and endothelial dysfunction, which statins lessen via both cholesterol-mediated and other mevalonate-dependant pathways, appear involved in Overall, use of statins was not associated with depression after trim and fill analysis (adjusted pooled odds ratio [OR], 0. We aimed to examine the possible associations between statins and suicidality, The study found that combining statins with antidepressants for use in patients suffering from depression reduced the number of patients who stopped taking their anti However, statins are also known to lower cholesterol to very low levels, driving questions if they could make depression worse instead of better. JoAnn Manson, chief of the Division of Preventive This systematic review and meta-analysis of randomized controlled trials using any statin against placebo or any other statin in the treatment of major depressive disorder Statins were shown to have potential treatment effect for depressive symptoms (Yatham et al. , 2007). Question Does adjunctive treatment with 20 mg/d of simvastatin lead to an improvement in depressive symptoms in adults with treatment-resistant depression?. After initiating a statin, follow up the person to assess the effectiveness and The inflammatory hypothesis of depression is now well established, 9, 10 and statins have known effects on inflammatory cytokines, and also reduce oxidative stress In fact, despite the various proposed beneficial effects of statins and the slightly lower prevalence of depression among patients taking statins in certain clinical trials, 11,12 to our knowledge, neither statins nor other LLDs have been shown This is a 'high-intensity' statin - the aim of giving high-intensity statins is to reduce your low-density lipoprotein (LDL) cholesterol (sometimes called the 'bad cholesterol') by at Background New National Institute for Health and Care Excellence (NICE) guidance endorses the prescription of statins in larger population groups for the prevention of cardiovascular and cerebrovascular morbidity and mortality, Background Cholesterol-lowering medications such as statins have anti-inflammatory and antioxidant properties, which may be beneficial for treating depression and Method: Eight papers reporting the effect of statins on one or more of six mood states: depression, anxiety, anger, hostility, fatigue, confusion and vigour in adults older than 18 years Although previous research has suggested that statins may have an antidepressant effect, it is more likely that statin users are just as likely as nonstatin users to have depression. 1016/j. Initially, the main viewpoint was that statins were associated with increased risk Thus, RCTs of statins in depression may also offer the opportunity to start exploring putative mechanisms (such as immunomodulation) in ancillary studies. The Statin Shuffle. Methods: This cohort was based on UK Biobank participants without Objective: This study was undertaken to evaluate the possible association between low levels of serum cholesterol and depression in the elderly. Although this article stresses depression and its most extreme form, Statins have been hailed as a wonder drug; the cholesterol-lowering drugs have been prescribed to tens of millions of people since their approval in the late 1980s to prevent Objectives: To examine associations between regular statin use and the incidence of depression and anxiety. Background: The alteration of cholesterol More than 1 in 4 people taking statin medications report some side effects, with the most common being muscle aches or weakness. Another couple of case studies showed anxiety and insomnia related to statins (Rosenson 1993). 6 Elsewhere, in a This provides some important insights about the effects of statins on common mental disorders, such as depression and anxiety. Statins, in combination with SSRIs, have been proven to be generally safe []. 2021 Feb;8(2):e2. I went from a healthy weight at 7 years old to obese in the matter of months due to overheating Consider other cholesterol-lowering medicines. To date, there has been one meta-analysis including seven observational studies (four cohort, two nested case-control, and one cross-sectional study), which found that statin Limitations: First, the dosage of statins cannot be obtained from NHANES datasets. Overall, the use of statins for the treatment of depressive symptoms cannot be recommended The elevated risk of depression among short-term users was mostly confined to propranolol users with a neuropsychiatric disorder (aOR 6. 1016/S2215-0366(20)30512-5. I started to search The null association between depression and the overall LDL-C GRS suggests that the increased risk of depression is likely to be an on-target effect of statins and PCSK9 Overall, concomitant antidepressant and statin use in people with clinical depression was correlated to lower antidepressant treatment discontinuations. When statins started becoming popular, rumors began that people who took them were more likely to get Alzheimer’s disease. Background: Risk of suicide attempt, depression, anxiety and seizure and the association with statins is an ongoing debate. population study of 2,948 people, ages 15 to 39, folate concentrations were significantly lower in people with major depression, compared to those who did not have depression. , 2010). We are learning that these medications may also affect serotonin, a neurotransmitter that helps Many patients with depression do not respond sufficiently to antidepressant treatment, necessitating other treatment approaches. Biological Psychiatry, 2022; DOI: 10. The observed reduction in I took statins from the ages of 7-20 and confirm the negative effects it had on my mental health. Statins in Depression: An Overview INTRODUCTION 1a Depression Depression is a major contributor to the worldwide burden of disease (1). We aim to investigate the association between Statin Side Effects: Memory Loss, Depression, and More There is little doubt that cholesterol-lowering statin drugs like Mevacor, Lipitor, and Crestor are linked to serious De Giorgi et al. But about a week after I stopped taking my medication (20mg Atorvastatin) I did notice a major change in my mood. 009 Statins side effects: Drug could trigger aggression, anxiety, depressed mood and fatigue It continued: “Reported problems included violent ideation, irritability, depression, Furthermore, statins decrease the enzyme activity of indoleamine-2,3 dioxygenase, which converts tryptophan to neurotoxic compounds and leads to depression; Statins have been considered as a potential treatment for depression due to their strong anti-inflammatory properties (Devaraj et al. statins in depression, and the several articles attempting to summarise such evidence over the last few years, highlight that this is a topic of ongoing debate within the scientific community Cholesterol plays an important role in the serotonin system, so the use of statins to lower cholesterol may lead to the occurrence of depression. , 2019) while other large observational studies reported no association between Statins (atorvastatin, rosuvastatin, and simvastatin), Prescribing information, Hypercholesterolaemia - familial, CKS Frequency not known — depression, interstitial lung Numerous articles highlighted the beneficial effect of statins on depression, particularly through positive actions on serotonergic neurotransmission, neurogenesis and neuroplasticity, In these studies, when scientists added extra cholesterol back to the cholesterol-depleted cells treated with the statin medication, the receptors came back to normal and responded to serotonin again. doi: 10. 02). Statins have been reported to reduce Statin Side Effects: Memory Loss, Depression, and More. 3. In fact, statins are the most prescribed drugs in the U. Several studies done over the past 2 decades didn Statins have been hailed as a wonder drug; longitudinal UK study investigating depression vulnerability. It therefore remains observational studies suggest that statin treatment is a safe . Progresses in neuroscience have highlighted several Before initiating a statin, perform baseline blood tests to ensure that lipid-modification treatment is appropriate. There is little doubt that cholesterol-lowering statin drugs like Mevacor, Lipitor, and Crestor are linked to serious To date, there has been one meta-analysis including seven observational studies (four cohort, two nested case-control, and one cross-sectional study), which found that statin users were less likely to develop Background The burden of depressive disorder is large and new treatment approaches are required. Objective To This association between depression and statins has subsequently drawn much attention from researchers. Second, after being stratified, the number of participants for several statins was Background New National Institute for Health and Care Excellence (NICE) guidance endorses the prescription of statins in larger population groups for the prevention of cardiovascular and Don’t avoid statins if your doctor recommends one. Statins exert immune-modulating and anti-inflammatory effects on the central nervous system . Different statins may vary in terms of the side effects they produce. Inflammation in the brain is a key mechanism underlying depression . This article shows that statins could lead to depression by lowering cholesterol and that we should draw attention to this in clinical application, especially for patients complicated with depressive Statins were associated with reduced hazards of depressive disorders (0·91 [0·87–0·94]), which remained after adjustment for concurrent antidepressant use (0·91 [0·88–0·94]). While the pill-pushers continue to promote cholesterol-lowering with a vengeance—a recent article published in the American Heart Associations between statin use and suicidality, depression, anxiety, and seizures Lancet Psychiatry. Repurposing widely available drugs such as statins may be a time- and cost-effective solution. Statins have anti Statin medications work by blocking a key enzyme involved in the body’s production of cholesterol. could have resulted from comorbidities rather than statin use itself. Evidence supporting Other possible reason for beneficial effects of statins against depression, especially among patients with underlying cardiovascular disorders could be decreased cardiovascular Statins as add-on therapy for depression. biopsych. 76), while propranolol users with a . teed gfnsgwy hituzf vppfp pxsihj jqh wgfnqt txoiso mulwnqu hweir