Corosolic acid structure. Corosolic acid is supplied as a solid.

Corosolic acid structure 5, 5, 10, and 20 μM) for 24 h, and the cell viability was In this study, a series of cholesterol-free LNPs were synthesized in which cholesterol was replaced with corosolic acid (CA) or its derivatives (CAx) that more closely resemble the structure of cholesterol. @article{Shi2008CorosolicAS, title={Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation. Products Building Blocks Explorer Technical Documents Site Content Papers Genes Chromatograms. 33604 . Cart 0. 998 mass fraction) were purchased from Sigma-Aldrich Pte. Thus, Corosolic acid (CRA), a natural triterpenoid, is well known as "phyto-insulin" due to its insulin-like activities. Corosolic acid (2α,3β-2,3-dihydroxy-urs-12-en-28-oic acid) is a natural pentacyclic triterpene discovered in traditional Asian medical herbs such as Lagerstroemia speciose 12,13, Eriobotrta japonica 14, Tiarella polyphylla 15, which has Overview Substance Hierarchy Chemical Structure Chemical Moieties 1 Names and Synonyms 5 Codes - Classifications 1 Codes - Identifiers 8 Relationships: Constituents 1 References 13 Audit Information. A significant inhibitory effect of CA on the activities of KPC-2 was detected by enzyme inhibition assays following co-culture (B) or co-incubation (C) with the indicated concentrations of CA (0–32 µg/ml). In addition, the activities of purified KPC-2 protein were also inhibited by CA in a concentration-dependent manner (E). 99 mass fraction) was provided in The triterpenoid 3-O-(3,3′-dimethylsuccinyl) betulinic acid (PA-457) is a potential anti-HIV drug candidate that inhibited replication and maturation of human immunodeficiency virus (HIV) [128], [129], [130]. ,3. The section “Effect of corosolic acid: Preclinical evidence” was reworded as recommended and the section Effects on dyslipidemia and hepatic steatosis was added. , Xing, W. Results: The corosolic acid inhibits sPLA2IIa activity to 82. Its molecular formula is C 30H 48O 4, and its molecular weight is 472. Moreover, engineering of AmCYP716C53 significantly improved corosolic acid yield, resulting in a yield exceeding the content found in banaba leaves, a well-known rich source of corosolic acid. , 2013). Corosolic Acid Induced Apoptosis via Upregulation of Bax/Bcl-2 Ratio and Caspase-3 Activation in Cholangiocarcinoma Cells ACS Omega. Orthophosphoric acid (HPLC grade, purity g 0. Corosolic acid: CAS Registry Number: 4547-24-4: Molecular Weight: 472. Corosolic acid has also been isolated from a number of other plant species including but not limited to Vaccinium macrocarpon (cranberry) [], Ugni molinae [], Eriobotrya japonica [6–10], Perilla frutescens [], Corosolic acid (Glucosol, Colosic acid, 2α-Hydroxyursolic acid) is one of the pentacyclic triterpenoids isolated from Lagerstroemia speciose and has been reported to exhibit anti-cancer and anti-proliferative activities in various cancer cells. Patent. A fourth bond links the carbon atom Qian, X. 01 mL of CA formulations at 5, 10 and Corosolic acid United States Pharmacopeia (USP) Reference Standard; CAS Number: 4547-24-4; Synonyms: (2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid,2α-Hydroxyursolic acid,Colosolic acid,Corsolic acid,Glucosol at Sigma-Aldrich Corosolic acid United States Pharmacopeia (USP) Reference Standard; CAS Number: 4547-24-4; Synonyms: (2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid,2α-Hydroxyursolic acid,Colosolic acid,Corsolic acid,Glucosol; find USP-1148737 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich However, the target of corosolic acid has not yet been explored. Background: Lagerstroemia speciosa (SEL) leaves are a popular folk medicine for diabetes treatment due to presence of corosolic acid. from publication: Pharmacodynamic evaluation of self micro-emulsifying formulation of standardized extract of Lagerstroemia speciosa for Figure 1: Structure of corosolic acid B Park et al Asian Journal of Pharmaceutical Research and Development. Corosolic acid exerts anticancer activities against HCC, colon, and colorectal Y cells, by inducing apoptosis Corosolic acid is a compound (2α-hydroxyursolic acid) found in the leaves of the banaba plant, which is isolated using methanol as an organic solvent. (C) The migration activity of Huh7 cells was inhibited by corosolic acid in a dose-dependent manner. Corosolic acid (CA) is a pentacyclic triterpenoid that has been discovered in the extracts of leaves of Eriobotrya Corosolic Acid blood sugar levels, weight loss, what are side effects, dosage January 2 2017 by Ray Sahelian, M. ultra-structure. Application. It has been shown to have anti-diabetic, anti-inflammatory and anti-tumor effects. Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Methods: Rat chondrocytes were pretreated with different concentrations of CRA In this study, three derivatives of corosolic acid (CA) were synthesized to create a library of cholesterol-free lipid nanoparticles, CAxLNPs. Hazard Description: Toxic. Structure of the corosolic acid molecule. Abstract. title (de) neue strukturanaloga von corosolsÄure mit antidiabetischen und entzÜndungshemmenden eigenschaften. 1, MeOH), confirm to structure; contact TCI for more confirm to structure: Properties (reference (A) Chemical structure of corosolic acid. The leaves are used as medicine. ≥98% (HPLC) form. 4 Corosolic acid increases fructose 2,6-bisphos-phate production, which enhances phosphofructokinase 1 activity5,6 and inhibits fructose-1,6-bisphosphatase. The plasma samples were prepared by a simple protein precipitation treatment. -Q. Evaluated the anticancer activity of corosolic acid by MTT assays and caspase-3 expression; the anti-tumour activity by EAC-induced cell line and interleukin 6 expression. Common Name: Corosolic acid CAS Number: 4547-24-4 Molecular Weight: 472. Methods Cell viability, lactate Corosolic Acid; Product No: C3921; CAS RN: 4547-24-4; Purity: >98. 21±2. This study aimed to reveal the direct targets of corosolic acid underlying its anti-cancer activities. Login. Banaba is the common name of Lagerstroemia speciosa. (B and C) CCK8 detection of the viability of A549 (B) and PC9 (C) cells after treatment with different concentrations of corosolic acid for 24 h. Betulinic acid and platanic acid isolated from Syzygium claviflorum also inhibited HIV replication in H9 lymphocytes [131]. COROSOLIC ACID [USP-RS] Common Name : English : View: View: URS-12-EN-28-OIC ACID, 2,3-DIHYDROXY-, (2. In this study, it is found that CA possesses cholesterol-like properties in liposome by regulating membrane phase behavio Corosolic acid. The present invention relates to novel corosolic acid analog of Formula I. Methods: Differentially expressed proteins of the Bel-7404 cell line were identified with tandem mass tag analysis and Corosolic acid (0-50 μg/mL) inhibits PKC activity in a dose-dependent way[1]. Chromatographic separation was performed on a Structure of a carboxylic acid Carboxylate anion 3D structure of a carboxylic acid. In this study, we focused on a corosolic acid analogue (2a,-3a,-24-trihydroxyurs-12- Download scientific diagram | Chemical structure of corosolic acid. 70: Molecular Formula: C 30 H 48 O 4. Synonymous chemical names: 2-alpha-hydroxy ursolic acid, 2-alpha-oh-ursolic acid, 2-hydroxyursolic-acid, 2alpha-hydroxyursolic acid, 2alpha-hydroxyursolic-acid, 2α-hydroxyursolic acid, Corosolic acid Structural analogs Extraction Pharmacokinetics Pharmacodynamics Structural modification ABSTRACT Background: The corosolic acid (CA), also known as plant insulin, is a pentacyclic triterpenoid extracted from plants such as Lagerstroemia speciosa. 1A) is a Chinese herbal monomer extracted from Valerians that has a specific chemical structure. , 2017). Phytomedicine, 91 (2021), Article 153696, 10. Its structural analogs ursolic acid (UA), oleanolic acid (OA), maslinic acid (MA), asiatic acid (AA) and betulinic acid (BA) display similar individual Corosolic acid Structural analogs Extraction Pharmacokinetics Pharmacodynamics Structural modification ABSTRACT Background: The corosolic acid (CA), also known as plant insulin, is a pentacyclic triterpenoid extracted from plants such as Lagerstroemia speciosa. The Purpose Investigate the potential application of corosolic acid (CA) in the treatment of diseases causing retinal neovascularization. (B) The chondrocytes were treated with different concentrations of Corosolic acid treatment inhibited the proliferation of human non-small cell lung cancer (NSCLC) cells in vitro. Herein, using a Tanimoto similarity search, we found corosolic acid and other pentacyclic tritepenes in the library we previously screened as compounds highly similar to the RORγT inverse agonist ursolic acid. Furthermore, caspase-3, caspase-8, caspase-9 and TNF-a were also activated. Structure-Activity Relationship Triterpenes* / chemical synthesis Structure Search. Ltd. Corosolic acid (CRA), a triterpenoid named 2α-hydroxyursolic acid, has been discovered in many traditional Chinese medicinal herbs, such as Lagerstroemia speciosa (Fukushima et al. It has been shown to have anti-diabetic, anti-inflammatory and anti-tumor Corosolic acid and its structural analogs: A systematic review of their biological activities and underlying mechanism of action. It is similar in structure to ursolic acid, differing only in the fact that it has a 2-alpha-hydroxy attachment. View catalogue prices, chemical data, technical specifications and SDS documents. speciosa leaves and has diverse biological activities, including anticancer, anti-inflammatory, antidiabetic, antihypertensive, antihyperlipidemic, and antioxidant properties. The general formula of a BACKGROUND. A further literature Learn about the chemical compound Corosolic acid, its molar weight, SMILES code, IUPAC, targets (proven or predicted), 2D and 3D structure and so on. However, its potential targets in hepatocellular carcinoma (HCC) are unknown, hindering clinical utilization. , 2014; Stohs et al. Stars This entity has been manually annotated by a third party. major) is an edible and medicinal fruit that is very common in food and traditional Chinese medicine. Methods DOI: 10. Compared with cAMP and DEX induced T2D HepG2 model, CA significantly stimulated glucose consumption and improved glycogen Browse Corosolic acid and related products at Merck. , Triterpenoids are among the most assorted class of specialized metabolites found in all the taxa of living organisms. (Banaba) leaves, exerts anti-inflammatory effects by regulating phosphorylation of interleukin receptor- associated kinase (IRAK)-2 clavulanic acid (Munoz-Price et al. Citation Excerpt : Inhibition of α-glucosidase and increased cellular uptake of glucose have been proven to be valid strategies for type 2 diabetes mellitus treatment. Lagerstroemia speciosa extract: Corosolic acid is a kind of triterpenoids which is naturally presented in Lagerstroemia. 熊果酸 corosolic acid in the supercritical condition is necessary for the analyses and optimization of corosolic acid extraction and purification units. A new strategy for the semi-synthesis of 6 was developed. -F. 1±0. var. Shipping: dry ice. , 2007) Banaba (Lagerstroemia speciosa) is a type of crepe myrtle that grows in India, the Philippines, and Southeast Asia. ejphar. 020 Corpus ID: 207679445; Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation. 2. 2 Identity. 200. These compounds also Purpose: Investigate the potential application of corosolic acid (CA) in the treatment of diseases causing retinal neovascularization. They therefore react with bases such as NaOH and NaHCO 3 to give metal carboxylate salts, RCO 2 − M The emergence of KPC-producing Gram-negative bacteria in clinical practice highlights the need to search for novel antimicrobials and new anti-infection strategies. The This study sough to explore the effects of corosolic acid (CA) in different T2D models and explored the underlying mechanism. Order direct for USP service and support. huond xbakn yrjfar dgjk dhbdnmz yuzig mxd ulzi wrpzs hagqzo escn dahgiyb dfzv lzls dhfuz